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Difference Between HGH and Sermorelin

Difference Between HGH and Sermorelin

October 10, 2018 hgh


Hormones are the body’s essential chemical messengers. Some have many functions, whereas others may have the sole responsibility of initiating the secretion of other hormones. That is one key difference between HGH and sermorelin.

HGH is human growth hormone, also called somatotropin (or somatropin for that which is created in a lab). It is a hormone secreted by cells in the anterior region of the pituitary gland called somatotrophs. The somatotrophs secrete HGH following delivery of another chemical growth hormone-releasing hormone (GHRH) sent from the hypothalamus.

When the supply of HGH declines, as it typically does with age, you can administer supplemental HGH to boost the amount in the bloodstream.

Sermorelin, on the other hand, functions much the same as GHRH. It is a secretagogue that influences the somatotrophs to increase HGH production.

What Does HGH Do for Growth Hormone Deficiency?

When comparing HGH vs. sermorelin, you must first learn if you are growth hormone deficient. The degree of GH decline helps determine the best option for treatment. HGH directly impacts growth hormone levels to reverse the symptoms of deficiency.

Supplemental HGH is bioidentical to the naturally derived growth hormone the somatotrophs secrete. If you have GH deficiency, along with symptoms of the decline, your body will likely need an immediate boost of HGH.

The primary difference between HGH and sermorelin is that Trusted sourceGrowth Hormone (Somatotropin)VIVO PathophysiologyGo to sourcehuman growth hormone therapy provides fast relief. By increasing available HGH for the body’s growth hormone receptor cells, you initiate immediate actions. These cells rely on a certain level of GH each day to carry out their functions. HGH injections naturally supply what is missing.

How Does Sermorelin Help Growth Hormone Deficiency?

Sermorelin is what is termed a secretagogue. That means it exerts its influence to cause the secretion of another substance – in this case, somatotropin.

When deciding between HGH or sermorelin, the symptoms and level of deficiency play a crucial role. Adults with very low growth hormone levels and multiple symptoms will require immediate HGH therapy. If, however, you are in the preliminary stages of GH decline, then sermorelin may be the better option.

A primary difference between HGH and sermorelin is in how they work. HGH injections do nothing to help improve the body’s natural growth hormone secretions. Sermorelin, on the other hand, enables the body to increase its own output of this vital hormone.

Because sermorelin works directly on the somatotrophs, the process of boosting HGH levels is slower. It will also take longer to see positive results. That is another reason why sermorelin is best when there are only minor symptoms of GH deficiency.

Sermorelin is a slower therapy designed to increase natural growth hormone secretion.

Can You Take HGH and Sermorelin Together?

There are pros and cons when looking at the difference between HGH and sermorelin. HGH works faster, immediately raising growth hormone levels. By doing so, however, HGH therapy also lets the hypothalamus know that there is enough growth hormone in the body. That fact tends to decrease natural somatotropin release.

Sermorelin, on the other hand, is a catalyst for growth hormone secretion. It helps promote more of a somatotropin release from the pituitary gland.

If you stop HGH therapy, your growth hormone levels may decline until the body restarts a higher output of somatotropin. That does not occur when you stop sermorelin therapy.

There is a solution that will work for some people – using sermorelin and HGH together.

When you receive a combination approach like this to treating growth hormone deficiency, you get the following benefits:

  • An immediate boost in HGH levels which can start to stimulate all the growth hormone receptors into action
  • Faster relief from the symptoms of growth hormone deficiency
  • Quicker results for energy, libido, appearance, brain functions, health, and weight loss
  • Maintaining a constant prompt to the pituitary gland to increase HGH secretion

When should a person with very low growth hormone levels use HGH and sermorelin combined?

The hormone doctor is the best person to make this determination. A thorough review of a person’s symptoms, blood test results, medical history, and examination findings will lead to a customized approach to raising growth hormone levels.

Please contact our hormone clinic to discuss your situation. We are here to answer your questions, provide comprehensive testing, and supply affordable treatment options to reverse growth hormone deficiency and its symptoms.

The Bottom Line: Your health is important. Our hormone specialists offer customized treatment options based on your body’s need. Contact us today for a free, confidential consultation.

Written by Author - Doctors/Authors Doctors/Authors - Medically reviewed by   Reviewers Reviewers - Updated on January 15, 2021

  1. Dr. Richard F Walker
  2. Tom Perls, MD, MPH, FACP, Neal R Reisman, MD, JD, S. Jay Olshansky, PhD
  3. Dr. Richard Walker

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