During my 40+ year career, I have worked at the interface between bone and endocrine neoplasia, specifically, multiple endocrine neoplasia type 2. I have been a leader in the development of strategies to prevent and treat medullary thyroid carcinoma (MTC): active in the development of prospective screening studies for hereditary medullary thyroid carcinoma, mapping and identifying RET as the causative gene, use of genetic information to direct prophylactic thyroidectomy, studies of tyrosine kinase inhibitors in the treatment of medullary thyroid carcinoma and studies to define how RET mutations cause MTC, the subject of the current proposal.
I have also an active leader in the bone field, being a charter member of the American Society of Bone and Mineral Research. I have been actively involved in basic and clinical studies of bone biology, particularly as they relate to bone health effects of cancer treatment. I have worked to define the role of calcitonin in bone biology, including the creation of a calcitonin knockout mouse model that defined a new function for this ancient hormone. My current work focuses on the role of the RET proto-oncogene in the genesis of bone metastasis in medullary thyroid carcinoma.
I have also served as Head of Internal Medicine at MD Anderson Cancer Center from 1995-2014, recruiting more than 125 of the current 185 faculty and redefining the role of Internal Medicine in a Center Center. During this time, I found time to remain engaged in laboratory and clinical pursuits, acquiring skills necessary for completion of this project.
Present Title & Affiliation
Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Adjunct Professor, Department of Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX
Education & Training
1971 Ohio State University, Columbus, OH, USA, BA, Arts-Medicine Program-resulting in both degrees being granted in 1971
1971 Ohio State University, Columbus, OH, USA, MD, Medicine
1973-1975 Fellow in Endocrinology, Tufts-New England Medical Center, Boston, MA
1972-1973 Resident in Medicine, Tufts-New England Medical Center, Boston, MA
1971-1972 Intern and resident in Internal Medicine, Tufts-New England Medical Center, Boston, MA
1977 Endocrinology and Metabolism
1975 Internal Medicine
Experience & Service
Co-Director, Rolanette and Berdon Lawrence Bone Disease Program of Texas, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 – 2012
Division Head, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 – 2014
Member, External Advisory Board, University of Cincinnati Cancer Center, Cincinnati, OH, 2004 – Present