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Robert F. Gagel

Robert F. Gagel

Author:

Larry Hale

, reviewed by:



Endocrinologist

Robert F. Gagel

Robert Gagel

1515 Holcombe Boulebard, Box 1463
Houston, TX, 77030
United States
Phone: 713-792-6517
Fax: 713-794-1818


POSITIONS Professor Medicine, Biochemistry, and Molecular & Cellular Biology Endocrinology, Diabetes and Metabolism Baylor College of Medicine Houston, TX, US

During my 40+ year career, I have worked at the interface between bone and endocrine neoplasia, specifically, multiple endocrine neoplasia type 2. I have been a leader in the development of strategies to prevent and treat medullary thyroid carcinoma (MTC): active in the development of prospective screening studies for hereditary medullary thyroid carcinoma, mapping and identifying RET as the causative gene, use of genetic information to direct prophylactic thyroidectomy, studies of tyrosine kinase inhibitors in the treatment of medullary thyroid carcinoma and studies to define how RET mutations cause MTC, the subject of the current proposal.

I have also an active leader in the bone field, being a charter member of the American Society of Bone and Mineral Research. I have been actively involved in basic and clinical studies of bone biology, particularly as they relate to bone health effects of cancer treatment. I have worked to define the role of calcitonin in bone biology, including the creation of a calcitonin knockout mouse model that defined a new function for this ancient hormone. My current work focuses on the role of the RET proto-oncogene in the genesis of bone metastasis in medullary thyroid carcinoma.

I have also served as Head of Internal Medicine at MD Anderson Cancer Center from 1995-2014, recruiting more than 125 of the current 185 faculty and redefining the role of Internal Medicine in a Center Center. During this time, I found time to remain engaged in laboratory and clinical pursuits, acquiring skills necessary for completion of this project.

Present Title & Affiliation

Primary Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Department of Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX

Education & Training

Degree-Granting Education

1971 Ohio State University, Columbus, OH, USA, BA, Arts-Medicine Program-resulting in both degrees being granted in 1971

1971 Ohio State University, Columbus, OH, USA, MD, Medicine

Postgraduate Training

1973-1975 Fellow in Endocrinology, Tufts-New England Medical Center, Boston, MA

1972-1973 Resident in Medicine, Tufts-New England Medical Center, Boston, MA

1971-1972 Intern and resident in Internal Medicine, Tufts-New England Medical Center, Boston, MA

Board Certifications

1977 Endocrinology and Metabolism

1975 Internal Medicine

Experience & Service

Administrative Appointments/Responsibilities

Co-Director, Rolanette and Berdon Lawrence Bone Disease Program of Texas, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 – 2012

Division Head, Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 – 2014

Other Appointments/Responsibilities

Member, External Advisory Board, University of Cincinnati Cancer Center, Cincinnati, OH, 2004 – Present


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